Research > SFCRI Investigators

SFCRI Investigators

This team of investigators with wide ranging expertise is committed to discovery — and that starts by investigating new methods of preventing, detecting and treating disease.


Charles Davies, MD

Charles Davies, MD, PhD

Physician in Neurology; Clinical Investigator
charles.davies@carle.com | (217) 383-3440

Education

PhD, Case Western Reserve University, Cleveland, Ohio, 1999
MD, Case Western Reserve University, Cleveland, Ohio, 2000
Residency Neurology, University of Michigan, Ann Arbor, Michigan, 2004
Fellowship Sleep Medicine, University of Michigan, Ann Arbor, Michigan, 2005

Research Interests

  • Cognitive effects of sleep disorders
  • Restless Legs Syndrome
  • Wearable sensors for sleep disorders
  • Impact of hormonal changes and environmental chemicals on sleep

Selected Publications

Yeh P, Ondo WG, Picchietti DL, Poceta JS, Allen RP, Davies CR, Wang L, Shi Y, Bagai K, Walters AS. Depth and Distribution of Symptoms in Restless Legs Syndrome/ Willis-Ekbom Disease. J Clin Sleep Med. 2016 Dec 5;12(12):1669-1680.

Davies CR, Harrington JJ. Impact of Obstructive Sleep Apnea on Neurocognitive Function and Impact of Continuous Positive Air Pressure. Sleep Med Clin. 2016 Sep;11(3):287-98.

Harrington J, Schramm PJ, Davies CR, Lee-Chiong TL Jr. An electrocardiogram-based analysis evaluating sleep quality in patients with obstructive sleep apnea. Sleep Breath. 2013 Sep;17(3):1071-8.

Manchanda S, Davies CR, Pichietti D. Celiac disease as a possible cause for low serum ferritin in patients with restless legs syndrome. Sleep Med. 2009 Aug; 10(7):763-5.

Teodorescu MC, Avidan AY, Teodorescu M, Harrington JJ, Artar AO, Davies CR, Chervin RD. Sleep medicine content of major medical textbooks continues to be underrepresented. Sleep Med. 2007 Apr;8(3):271-6.


Sean T Grambart, DPM

Sean T Grambart, DPM

Podiatrist in Orthopedics; Clinical Investigator
sean.grambart@carle.com | (217) 383-9400

Education

DPM, University of Osteopathic Medicine and Health Sciences, Des Moines, Iowa, 2001
Fellowship AO Trauma and Reconstruction, Klinik fur Unfall und Wiederherstellungschirurgie Universitatsklinikum Carl-Gustav-Carus, Dresden, Germany, 2003
Residency Podiatric Medicine, Swedish Medical Center, Seattle, Washington, 2004

Research Interests

  • Foot/ankle reconstruction and trauma
  • Sports medicine
  • Arthroscopy

Selected Publications

Grambart ST. Arthroscopic Management of Osteochondral Lesions of the Talus. Clin Podiatr Med Surg. 2016 Oct;33(4):521-30. doi: 10.1016/j.cpm.2016.06.008. Review. PubMed PMID: 27599437.

Grambart ST. Imaging of Common Arthroscopic Pathology of the Ankle. Clin Podiatr Med Surg. 2016 Oct;33(4):493-502. doi: 10.1016/j.cpm.2016.06.007. Review. PubMed PMID: 27599435.

Grambart ST. Hibbs Tenosuspension. Clin Podiatr Med Surg. 2016 Jan;33(1):63-9. doi: 10.1016/j.cpm.2015.07.001. Epub 2015 Aug 29. Review. PubMed PMID: 26590725.

Grambart ST. Sports medicine and platelet-rich plasma: nonsurgical therapy. Clin Podiatr Med Surg. 2015 Jan;32(1):99-107. doi: 10.1016/j.cpm.2014.09.006.

Grambart ST, Overley BD Jr. Preoperative evaluation and testing for arthroscopy. Clin Podiatr Med Surg. 2011 Jun;28(3):453-67. doi: 10.1016/j.cpm.2011.04.007. Review. PubMed PMID: 21777778.


Anna Higham, MD

Anna Higham, MD

Physician in Oncology; Clinical Investigator
anna.higham@carle.com | (217) 383-3010

Education

MD, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, 2008
Residency General Surgery, Northwestern McGaw Medical Center, Chicago, Illinois, 2013
Fellowship Breast Oncology, Northwestern McGaw Medical Center, Chicago, Illinois, 2014

Research Interests

  • Breast cancer
  • Benign breast disease
  • Patients at high risk for breast cancer

Selected Publications

Stelle L, Schoenheit T, Brubaker A, Tang X, Qu P, Cradock K, Higham A. Radioactive Seed Localization Versus Wire Localization for Nonpalpable Breast Lesions: A Two-Year Initial Experience at a Large Community Hospital. Ann Surg Oncol. 2018 Jan;25(1):131-136.

Karavites LC, Kane AK, Zaveri S, Xu Y, Helenowski I, Hansen N, Bethke KP, Rasmussen-Torvik LJ, Khan SA. Tamoxifen Acceptance and Adherence among Patients with Ductal Carcinoma In Situ (DCIS) Treated in a Multidisciplinary Setting. Cancer Prev Res (Phila). 2017 Jul;10(7):389-397.


Graham R Huesmann, MD, PhD

Graham R Huesmann, MD, PhD

Physician in Neurology; Clinical Investigator
graham.huesmann@carle.com | (217) 383-3440

Education

PhD, University of Illinois College of Medicine, Urbana-Champaign, Illinois, 2005
MD, University of Illinois College of Medicine, Urbana-Champaign, Illinois, 2007
Residency Neurology, Partners Neurology, Massachusetts General Hospital, Brigham and Women’s Hospital, Harvard Medical School, 2011
Fellowship Epilepsy, Massachusetts General Hospital, Harvard Medical School, 2013

Research Interests

  • Acute and ICU epilepsy monitoring
  • Pathophysiology of epileptogenesis
  • Rapid diagnosis and treatment to prevent lifelong disability
  • The role of Caspase-3 in suppressing synaptic communication
  • Targeting activation of neuronal Caspase-3 as a novel epilepsy therapy
  • Epileptogenesis in cortical dysplasias

Selected Publications

Johnson CL, Schwarb H, D J McGarry M, Anderson AT, Huesmann GR, Sutton BP, Cohen NJ. Viscoelasticity of subcortical gray matter structures. Hum Brain Mapp. 2016 Dec;37(12):4221-4233.

Mackay DD, Huesmann GR, Wu RI, Stone JR, Pless ML. Giant cell arteritis causing symmetric bilateral posterior circulation infarcts. J Clin Rheumatol. 2013 Oct;19(7):393-6.

Huesmann GR, Clayton DF. Dynamic role of postsynaptic caspase-3 and BIRC4 in zebra finch song-response habituation. Neuron. 2006 Dec 21;52(6):1061-72.

Davies SA, Stewart EJ, Huesmann GR, Skaer NJ, Maddrell SH, Tublitz NJ, Dow JA. Neuropeptide stimulation of the nitric oxide signaling pathway in Drosophila melanogaster Malpighian tubules. Am J Physiol. 1997 Aug;273(2 Pt 2):R823-7.

O'Donnell MJ, Dow JA, Huesmann GR, Tublitz NJ, Maddrell SH. Separate control of anion and cation transport in malpighian tubules of Drosophila Melanogaster. J Exp Biol. 1996 May;199(Pt 5):1163-75.


Leanne Labriola, DO

Leanne Labriola, DO

Physician in Ophthalmology; Clinical Investigator
leanne.labriola@carle.com | (217) 383-3150

Education

DO, Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania, 2006
Residency Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, 2010
Fellowship Medical Retina, Doheny Eye Institute University of Southern California, Los Angeles, California, 2011

Research Interests

  • Ophthalmic imaging
  • Diagnostic improvements for ophthalmology
  • Novel tear film biomarkers
  • Ocular tissue regeneration

Selected Publications

Bhaduri B, Shelton RL, Nolan RM, Hendren L, Almasov A, Labriola LT, Boppart SA. Ratiometric analysis of optical coherence tomography-measured in vivo retinal layer thicknesses for the detection of early diabetic retinopathy. J
Biophotonics. 2017 Nov;10(11):1430-1441.

Khan MS, Misra SK, Schwartz-Duval AS, Daza E, Ostadhossein F, Bowman M, Jain A, Taylor G, McDonagh D, Labriola LT, Pan D. Real-Time Monitoring of Post-Surgical and Post-Traumatic Eye Injuries Using Multilayered Electrical Biosensor Chip. ACS Appl Mater Interfaces. 2017 Mar 15;9(10):8609-8622

Papke D, McNussen PJ, Rasheed M, Tsipursky MS, Labriola LT. A Case of Unilateral Optic Neuropathy Following Influenza Vaccination. Semin Ophthalmol. 2017;32(4):517-523.

Labriola LT, Legarreta AD, Legarreta JE, Nadler Z, Gallagher D, Hammer DX, Ferguson RD, Iftimia N, Wollstein G, Schuman JS. Imaging with multimodal adaptive-optics optical coherence tomography in multiple evanescent white dot syndrome: the structure and function relationship. Retin Cases Brief Rep. 2016 Fall;10(4):302-9.

Gartia MR, Misra SK, Ye M, Schwartz-Duval A, Plucinski L, Zhou X, Kellner D, Labriola LT, Pan D. Point-of-service, quantitative analysis of ascorbic acid in aqueous humor for evaluating anterior globe integrity. Sci Rep. 2015 Nov
3;5:16011. Erratum in: Sci Rep. 2016;6:20452.
Daniel L Picchietti, MD

Daniel L Picchietti, MD

Physician in Sleep Medicine; Clinical Investigator
daniel.picchietti@carle.com | (217) 383-3100

Education

MD, University of Chicago, Chicago, Illinois, 1979
Residency Pediatrics, St. Louis Children's Hospital, St. Louis, Missouri, 1981
Fellowship Neurology, University of Chicago, Chicago, Illinois, 1984

Research Interests

  • Sleep disorders in adults and children
  • Sleep apnea
  • Restless legs syndrome
  • Narcolepsy
  • Attention deficit disorder (ADD)

Selected Publications

Allen RP, Picchietti DL, Auerbach M, Cho YW, Connor JR, Earley CJ, et al. Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report. Sleep Medicine. 2018;41:27-44.

Picchietti DL. Should oral iron be first-line therapy for pediatric restless legs syndrome and periodic limb movement disorder? Sleep Med. 2017 Apr;32:220-221.

Yeh P, Ondo WG, Picchietti DL, Poceta JS, Allen RP, Davies CR, Wang L, Shi Y, Bagai K, Walters AS. Depth and Distribution of Symptoms in Restless Legs Syndrome/ Willis-Ekbom Disease. J Clin Sleep Med. 2016 Dec 15;12(12):1669-1680.

Picchietti DL, Bruni O, de Weerd A, Durmer JS, Kotagal S, Owens JA, et al. Pediatric restless legs syndrome diagnostic criteria: An update by the International Restless Legs Syndrome Study Group. Sleep Med. 2013;14:1253-9.

Picchietti D, Allen RP, Walters AS, Davidson JE, Myers A, Ferini-Strambi L. Restless legs syndrome: prevalence and impact in children


Blair Rowitz, MD

Blair Rowitz, MD

Physician in Bariatrics and General Surgery; Clinical Investigator
blair.rowitz@carle.com | (217) 326-5054

Education

MD, Rush Medical College, Chicago, Illinois, 1993
Residency General Surgery, Allegheny General Hospital, Pittsburgh, Pennsylvania, 1997

Research Interests

  • Metabolic effects and clinical outcomes following bariatric surgery
  • Perioperative risk modification
  • Intestinal stents for the treatment of small bowel perforations
  • Obesity in trauma

Selected Publications

Robinson K, Rowitz B, Teran-Garcia M. One year later: are dietary changes maintained following sleeve gastrectomy? Surg Obes Relat Dis. 2017 Oct; 13(10 Suppl): S202.

Osborne Z, Rowitz B, Moore H, Oliphant U, Butler J, Olson M, Aucar J. Obesity in trauma: outcomes and disposition trends. Am J Surg. 2014 Mar;207(3):387-92; discussion 391-2. doi: 10.1016/j.amjsurg.2013.10.013. Epub 2013 Dec 19. PubMed PMID: 24581763.


Kendrith M Rowland, MD

Kendrith M Rowland, MD

Physician in Oncology; Clinical Investigator
kendrith.rowland@carle.com | (217) 383-3010

Education

MD, University of Illinois Abraham Lincoln School of Medicine, Chicago, Illinois, 1980
Residency Internal Medicine, University of Illinois Hospital, Chicago, Illinois, 1983
Fellowship Rush Medical Center, Chicago, Illinois, 1985

Research Interests

  • Breast cancer
  • Novel therapeutics

Selected Publications

Witzig TE, Johnston PB, LaPlant BR, Kurtin PJ, Pederson LD, Moore DF Jr, Nabbout NH, Nikcevich DA, Rowland KM, Grothey A. Long-term follow-up of chemoimmunotherapy with rituximab, oxaliplatin, cytosine arabinoside, dexamethasone (ROAD) in patients with relapsed CD20+ B-cell non-Hodgkin lymphoma: Results of a study of the Mayo Clinic Cancer Center Research Consortium (MCCRC) MC0485 now known as academic and community cancer research united (ACCRU). Am Hematol. 2017 Oct;92(10):1004-1010.

Jatoi A, Steen PD, Atherton PJ, Moore DF, Rowland KM, Le-Lindqwister NA, Adonizio CS, Jaslowski AJ, Sloan J, Loprinzi C. A double-blind, placebo-controlled randomized trial of creatine for the cancer anorexia/weight loss syndrome (N02C4): an Alliance trial. Ann Oncol. 2017 Aug 1;28(8):1957-1963.

Zhao Y, Foster NR, Meyers JP, Thomas SP, Northfelt DW, Rowland KM Jr, Mattar BI, Johnson DB, Molina JR, Mandrekar SJ, Schild SE, Bearden JD 3rd, Aubry MC, Adjei AA. A phase I/II study of bortezomib in combination with paclitaxel, carboplatin, and concurrent thoracic radiation therapy for non-small-cell lung cancer: North Central Cancer Treatment Group (NCCTG)-N0321. J Thorac Oncol. 2015 Jan;10(1):172-80.

Maunsell E, Goss PE, Chlebowski RT, Ingle JN, Alés-Martínez JE, Sarto GE, Fabian CJ, Pujol P, Ruiz A, Cooke AL, Hendrix S, Thayer DW, Rowland KM, Dubé P, Spadafora S, Pruthi S, Lickley L, Ellard SL, Cheung AM, Wactawski-Wende J, Gelmon KA, Johnston D, Hiltz A, Brundage M, Pater JL, Tu D, Richardson H. Quality of life in MAP.3 (Mammary Prevention 3): a randomized, placebo-controlled trial evaluating exemestane for prevention of breast cancer. J Clin Oncol. 2014 May 10;32(14):1427-36.


Christine Wetzel, RN

Christine Wetzel, RN

Nurse in Neonatal ICU; Clinical Investigator
chris.wetzel@carle.com | (217) 383-3266

Education

ADN, Parkland College, Champaign, Illinois, 1993
MSN, University of Phoenix, Phoenix, Arizona, 2005

Research Interests

  • Breastmilk to prevent necrotizing enterocolitis (NEC), sepsis and death
  • Interventions to maintain the maternal breastmilk during the premature infant’s hospitalization
  • The premature microbiome
  • Prevention of feeding intolerance and NEC

Selected Publications

Gephart SM, Hanson C, Wetzel CM, Fleiner M, Umberger E, Martin L, Rao S, Agrawal A, Marin T, Kirmani K, Quinn M, Quinn J, Dudding KM, Clay T, Sauberan J, Eskenazi Y, Porter C, Msowoya AL, Wyles C, Avenado-Ruiz M, Vo S, Reber KM, Duchon J. NEC-zero recommendations from scoping review of evidence to prevent and foster timely recognition of necrotizing enterocolitis. Matern Health Neonatol Perinatol. 2017 Dec 18;3:23.

Naberhuis J, Wetzel C, Tappenden KA. A Novel Neonatal Feeding Intolerance and Necrotizing Enterocolitis Risk-Scoring Tool Is Easy to Use and Valued by Nursing Staff. Adv Neonatal Care. 2016 Jun;16(3):239-44.

Gephart SM, Wetzel C, Krisman B. Prevention and early recognition of necrotizing enterocolitis: a tale of 2 tools--eNEC and GutCheckNEC. Adv Neonatal Care. 2014 Jun;14(3):201-10.


Karen White, MD, PhD

Karen White, MD, PhD

Physician in Critical Care; Clinical Investigator
karen.white@carle.com | (217) 904-7514

Education

PhD, Pennsylvania State University, University Park, Pennsylvania, 1991
MD, University of Illinois College of Medicine, Urbana, Illinois, 2001
Residency Internal Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, 2004
Fellowship Critical Care, St. John's Mercy Medical Center and St. Louis University, St. Louis, Missouri, 2006

Research Interests

  • Develop methods to identify early stages of sepsis in patients
  • Create biomarker panels
  • Identify effective treatments for inflammation due to sepsis
  • Create tablet-based platforms for ACLS and sepsis protocols for easy management

Selected Publications

Taneja I, Reddy B, Damhorst G, Dave Zhao S, Hassan U, Price Z, Jensen T, Ghonge T, Patel M, Wachspress S, Winter J, Rappleye M, Smith G, Healey R, Ajmal M, Khan M, Patel J, Rawal H, Sarwar R, Soni S, Anwaruddin S, Davis B, Kumar J, White K, Bashir R, Zhu R. Combining Biomarkers with EMR Data to Identify Patients in Different Phases of Sepsis. Sci Rep. 2017 Sep 7;7(1):10800.

Hassan U, Ghonge T, Reddy B Jr, Patel M, Rappleye M, Taneja I, Tanna A, Healey R, Manusry N, Price Z, Jensen T, Berger J, Hasnain A, Flaugher E, Liu S, Davis B, Kumar J, White K, Bashir R. A point-of-care microfluidic biochip for quantification of CD64 expression from whole blood for sepsis stratification. Nat Commun. 2017 Jul 3;8:15949.